Mechanisms underlying full regeneration of mammalian tissues remain poorly understood. Our research is defining the molecular and biophysical drivers of tissue healing at organ scale. We seek to leverage this knowledge to establish better therapeutic strategies for patients.
We are motivated by one question:How do varied cells synchronize their activity to restore damaged tissue?
Training Philosophy
The SRSPL exists to uncover new scientific knowledge in biomedicine and to train bright talent in the art of science. We regard training as a core pillar of the missional advancement of the lab and of academic science.
The SRSPL utilizes a trainee-focused approach to mentorship. We view the role of the lab as one that provides a scientific platform that trainees can use to build upon for advancing their careers, their professional goals, and to reach their full scientific potential. This approach is based on a strength-based model of scientific development rather than a deficit remediation approach. In this model, each trainee's attributes and existing skillsets are nurtured, rather than an emphasis on remediation of seemingly lacking attributes. This approach is based on the recognition that if a trainee is admitted into SRSPL, they have met the core competencies to be a successful scientist, thus the sole role of the lab is to create the intellectual working environment necessary to maximize scientific potential.
Transdisciplinary Science
Our research focuses on understanding the molecular and cellular cross-talks enabling healing of large-scale tissue injuries, and we explore a wide range of scientific disciplines to gain this understanding. The SRSPL practices convergence science and overlaps many scientific disciplines, namely cell biology, genetics, biophysics, mathematics, and systems bioengineering. The lab takes a strong teams-based approach to experimental design and execution. Consequently, we are a transdisciplinary lab affiliated with three separate departments, and several research centers, across two distinct schools at Columbia University — the School of Medicine and the School of Engineering.
Inclusive Excellence
Solving the mammalian tissue regeneration puzzle requires novel, paradigm-shifting, concepts fueled by the most innovate and ingenious of ideas. Thus, we believe contributions from a diversity of intellects, experiences, skills, and perspectives is our best hope. These diverse attributes dwell within humans who come in all kinds and varieties. SRSPL is consequently located in Manhattan, NY — one of the most diverse locales of the modern world, to readily improve, harness, and leverage this incredible resource.
